We have developed our proprietary RED PLATFORM® to generate red blood cells and biologically engineer them into a new class of cellular medicines, called Red Cell Therapeutics™ (RCTs). Our RED PLATFORM harnesses both the unique properties of red blood cells and the creative potential of biological engineering to deliver on the promise of cellular therapy and transform how diseases are treated.
Red Cell Therapeutics are engineered to express biotherapeutic proteins within or on their cell surface to create highly selective, potent and allogeneic cellular medicines aimed at treating a range of diseases. They can potentially be used to kill tumors in cancer, regulate the immune system for the treatment of autoimmune diseases and treat a number of other types of illnesses.
By leveraging distinct therapeutic modalities, including immune system activation and tolerance induction, our initial RCTs have the potential to improve the treatment of cancer and autoimmune diseases and treat a number of other types of illnesses.
Our allogeneic Red Cell Therapeutic oncology product candidates are engineered to express...
Our allogeneic Red Cell Therapeutic oncology product candidates are engineered to express hundreds of thousands of co-stimulatory molecules and cytokines on the surface of the cell to restore immune system function by stimulating adaptive and innate immunity to generate an anti-tumor immune response.
LessWe can engineer our cells to express specific autoimmune disease-associated antigens either within or on the cell surface...
We can engineer our cells to express specific autoimmune disease-associated antigens either within the cell or on the cell surface to take advantage of how the body normally maintains self-tolerance, thereby retraining the immune system to no longer see self-antigens as foreign.
In addition, we have the ability to express immune modulating cytokines, enzymes or inhibitory signals, which may have the potential to enhance the tolerogenic effects of our Red Cell Therapeutics.
We believe RCTs can be designed to specifically modulate complex counter-regulatory immune responses, which may enable efficacy with minimal side effects, potentially providing treatments for a number of diseases, and, in some cases, even cures.
With the RED PLATFORM®, Rubius Therapeutics can generate a wide variety of allogeneic, ready-to-use RCTTM product candidates with our proprietary process: